| Fixtures |
| Game Week |
Date |
Competition |
Fixture |
Result |
| 36 |
2022-05-17 |
English Premier League |
Southampton v Liverpool |
1 v 2 |
| 35 |
2022-05-07 |
English Premier League |
Brentford v Southampton |
3 v 0 |
| 34 |
2022-04-30 |
English Premier League |
Southampton v Crystal Palace |
1 v 2 |
| 33 |
2022-04-24 |
English Premier League |
Brighton v Southampton |
2 v 2 |
| 32 |
2022-04-21 |
English Premier League |
Burnley v Southampton |
2 v 0 |
| 32 |
2022-04-16 |
English Premier League |
Southampton v Arsenal |
1 v 0 |
| 31 |
2022-04-09 |
English Premier League |
Southampton v Chelsea |
0 v 6 |
| 30 |
2022-04-02 |
English Premier League |
Leeds United v Southampton |
1 v 1 |
| 29 |
2022-03-20 |
English FA Cup |
Southampton v Manchester City |
1 v 4 |
| 28 |
2022-03-13 |
English Premier League |
Southampton v Watford |
1 v 2 |
| 27 |
2022-03-10 |
English Premier League |
Southampton v Newcastle United |
1 v 2 |
| 27 |
2022-03-05 |
English Premier League |
Aston Villa v Southampton |
4 v 0 |
| 26 |
2022-03-02 |
English FA Cup |
Southampton v West Ham United |
3 v 1 |
| 26 |
2022-02-25 |
English Premier League |
Southampton v Norwich City |
2 v 0 |
| 25 |
2022-02-19 |
English Premier League |
Southampton v Everton |
2 v 0 |
| 24 |
2022-02-12 |
English Premier League |
Manchester United v Southampton |
1 v 1 |
| 23 |
2022-02-09 |
English Premier League |
Tottenham Hotspur v Southampton |
2 v 3 |
| 23 |
2022-02-05 |
English FA Cup |
Southampton v Coventry City |
2 v 1 |
| 21 |
2022-01-22 |
English Premier League |
Southampton v Manchester City |
1 v 1 |
| 20 |
2022-01-15 |
English Premier League |
Wolverhampton Wanderers v Southampton |
3 v 1 |
| 19 |
2022-01-11 |
English Premier League |
Southampton v Brentford |
4 v 1 |
| 19 |
2022-01-08 |
English FA Cup |
Swansea City v Southampton |
2 v 3 |
| 17 |
2021-12-28 |
English Premier League |
Southampton v Tottenham Hotspur |
1 v 1 |
| 17 |
2021-12-26 |
English Premier League |
West Ham United v Southampton |
2 v 3 |
| 15 |
2021-12-15 |
English Premier League |
Crystal Palace v Southampton |
2 v 2 |
| 15 |
2021-12-11 |
English Premier League |
Arsenal v Southampton |
3 v 0 |
| 14 |
2021-12-04 |
English Premier League |
Southampton v Brighton |
1 v 1 |
| 13 |
2021-12-01 |
English Premier League |
Southampton v Leicester City |
2 v 2 |
| 13 |
2021-11-27 |
English Premier League |
Liverpool v Southampton |
4 v 0 |
| 12 |
2021-11-20 |
English Premier League |
Norwich City v Southampton |
2 v 1 |
| 11 |
2021-11-05 |
English Premier League |
Southampton v Aston Villa |
1 v 0 |
| 10 |
2021-10-30 |
English Premier League |
Watford v Southampton |
0 v 1 |
| 9 |
2021-10-26 |
English League Cup |
Chelsea v Southampton |
1 v 1 |
| 9 |
2021-10-23 |
English Premier League |
Southampton v Burnley |
2 v 2 |
| 8 |
2021-10-16 |
English Premier League |
Southampton v Leeds United |
1 v 0 |
| 7 |
2021-10-02 |
English Premier League |
Chelsea v Southampton |
3 v 1 |
| 6 |
2021-09-26 |
English Premier League |
Southampton v Wolverhampton Wanderers |
0 v 1 |
| 5 |
2021-09-21 |
English League Cup |
Sheffield United v Southampton |
2 v 2 |
| 5 |
2021-09-18 |
English Premier League |
Manchester City v Southampton |
0 v 0 |
| 4 |
2021-09-11 |
English Premier League |
Southampton v West Ham United |
0 v 0 |
| 3 |
2021-08-28 |
English Premier League |
Newcastle United v Southampton |
2 v 2 |
| 2 |
2021-08-25 |
English League Cup |
Newport County v Southampton |
0 v 8 |
| 2 |
2021-08-22 |
English Premier League |
Southampton v Manchester United |
1 v 1 |
| 1 |
2021-08-14 |
English Premier League |
Everton v Southampton |
3 v 1 |
